I don't know... I am curently working on an Engineering degree, so I'm familiar with some of the jokes just from a lot of physics and chem classes. But the majority of the humor is just as easy to pick up on as any other show. My mom watches that show religiously, but is math/science illiterate... So all those jokes go over her head but she still loves that show. Most of the references aren't supposed to get picked up on. String theory isn't exactly a simple subject.